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Novel Repurposed Therapy We are the first biotechnology company to pioneer the development and commercialization of novel redesigned and repurposed artemisinin anti-malarial compounds for the treatment of cancer, inflammation and infectious diseases.
Targeted Therapy Our proprietary technologies are based on novel artemisinin compounds and combination products in which artemisinin derivatives are attached to iron-binding molecules and cell receptor-targeting molecules for selective and effective delivery into target disease cells.
Smart Drug and Trojan Horse Our artemisinin compounds act as "Smart Drugs" and "Trojan Horses" that selectively destroy cancer cells and other abnormally proliferating cells, without harming normal cells. These effects have been observed and confirmed in numerous preclinical studies. Artemisinin is not activated until it comes into contact with free iron inside a cell. Since cancer cells typically contain higher levels of uncontrolled free iron than normal cells, they are more susceptible to the toxic effects of artemisinin. Another advantage of artemisinin-based therapies is that they have been found to inhibit multiple targets and up/downstream pathways involved in cancer and inflammatory diseases.
Artemisinin Artemisinin is the active ingredient found in the sweet wormwood plant (Artemisia annua L.) whose medicinal value was first discovered more than 2,000 years ago in China where the plant has been used to treat a variety of ailments. However, since scientists first isolated artemisinin in the early the 1970's, artemisinin and its derivatives have been best known and used as potent gold standard anti-malarial agents. Artemisinin is a chemical called a sesquiterpene lactone that contains an endoperoxide bridge, or internal double-oxygen bridge, which breaks down to form carbon-based free radicals when it comes into contact with free ferrous iron. This reaction is selectively toxic to cells with uncontrolled or elevated free iron levels, such as cancer cells and the abnormally proliferating cells found in diseases such as psoriasis, enlarged prostate, and proliferative eye and kidney diseases.
In addition, artemisinin compounds exhibit potent anti-inflammatory effects like "aspirin on steroids" and should be beneficial in the management of inflammation in diverse conditions that include RA, asthma, COPD, lupus, MS, cystic fibrosis, polycystic kidney disease and others.
Artemisinin and its derivatives have been used as life-saving malaria drugs for more than 30 years by millions of patients worldwide, are well-characterized, and have outstanding therapeutic and safety profiles.
Artemisinin is indeed a unique natural product. Despite extensive research and screening of thousands of plants containing sesquiterpene lactones, artemisinin remains the only known natural product to contain a 1,2,4-trioxane ring structure, and Artemisia annua continues to be the only known natural source.